15-Hydroxyeicosatetraenoic Acid and GPR39 Together Orchestrate Coronary Autoregulation: A Comprehensive Metabolomic Analysis
D. Elizabeth Le, Masaki Kajimoto, Yan Zhao, Carmen Methner, Zhiping Cao, Jessica Minner, Agostino Cianciulli, Teresa Semeraro, Iuni Margaret Laura Trist, Jessica Franchi, chiara marcheselli, Alberto Parazzoli, Fabrizio Micheli, Sanjiv Kaul
This paper identifies GPR39 and 15-HETE as key regulators of coronary autoregulation through in vivo experiments and metabolomic analysis in dogs.
bioRxiv · Aug 9, 2026 · PreprintPhysiology