Yan Zhao

A PTN-Rich MSC Subtype Promotes Cartilage Repair in End-Stage Knee Osteoarthritis

The paper identifies a PTN-rich MSC subtype that enhances cartilage repair in KOA by modulating key inflammatory and repair pathways.

The cleaved C-terminal domain of GmERS1-1 modulates cell cycle via GmACR1

This study identifies a proteolytic processing mechanism of the soybean ethylene receptor GmERS1-1 that modulates cell cycle progression via interaction with GmACR1 and GmCDK7.

Maintenance of quantitative genetic variation in regions of restricted recombination via associative overdominance

The paper shows that weakly selected QTLs linked to regions with associative overdominance can increase additive genetic variance, but recessive deleterious alleles may reduce fitness when exposed by selection.

15-Hydroxyeicosatetraenoic Acid and GPR39 Together Orchestrate Coronary Autoregulation: A Comprehensive Metabolomic Analysis

This paper identifies GPR39 and 15-HETE as key regulators of coronary autoregulation through in vivo experiments and metabolomic analysis in dogs.

Nature-Inspired Nanoparticle Adiposomes Enable Targeted Delivery of Hydrophobic Drug for Anti-Cancer Treatment

This paper develops adiposomes, a biocompatible nanoparticle platform for hydrophobic drug delivery, showing improved efficacy and reduced toxicity in cancer models.

Hierarchical Anchoring Gating Dictates Specific H4K16 Acetylation by the Human MSL Complex

This study identifies a hierarchical anchoring-gating mechanism in the MSL complex that ensures specific H4K16 acetylation and reveals its role in chromatin accessibility and transcription.

New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions

The paper generates new alleles of BIK1 and PBL1 using CRISPR-Cas9 and shows their central role in pattern-triggered immunity, while highlighting pleiotropic effects of T-DNA insertions.

Generalization but not strengthening of negative memories drives the development of depression-like behaviors

The study distinguishes between memory strengthening and generalization, finding that memory generalization, not strengthening, drives depression-like behaviors through mPFC-BNST circuit mechanisms.

VISTA-induced tumor suppression by a four amino acid intracellular motif

This study identifies a four amino acid motif in VISTA that suppresses tumor growth by altering EGFR signaling through NUMB recruitment.

Bovine H5N1 influenza virus binds poorly to human-type sialic acid receptors

This study shows that clade 2.3.4.4b H5N1 influenza viruses bind efficiently to avian-type sialic acid receptors but not human-type receptors.

Exosomal MFGE8 from high glucose induced endothelial cells is involved in calcification/senescence of vascular smooth muscle cells

This study identifies exosomal MFGE8 from high glucose-induced endothelial cells as a mediator of vascular smooth muscle cell calcification and senescence in diabetic vascular aging.

Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy

The paper reports the cryo-EM structure of the GluA2 AMPA receptor complex with TARP γ2 subunits, revealing their arrangement and interactions with the receptor.