Selective Pharmacological Blockade of GPR39 Markedly Reduces No Reflow and Infarct Volumes in a Rat Acute Myocardial Infarction When Administered Prior to Reperfusion
Carmen Methner, Mary Plascencia, allura thompson, Lijuan Liu, Masaki Kajimoto, D. Elizabeth Le, Agostino Cianciulli, Annalisa Pellacani, Jessica Franchi, chiara marcheselli, Alberto Parazzoli, Fabrizio Micheli, Sanjiv Kaul
Single intravenous bolus of the GPR39 antagonist VC108 shrank infarct and no-reflow volumes in rat myocardial infarction when given before reperfusion, but not 30 min after reperfusion.
bioRxiv · Aug 14, 2026 · PreprintPhysiology✦ In-depth digest