Molecular-level analysis of serum IgG repertoires in COVID-19-vaccinated people with cystic fibrosis identifies abundant convergent antibodies
Steven Ionov, Ruth I. Connor, Nicholas C. Curtis, Seungmin Shin, Brian H. Kim, Niklas Koehne, Ji-Ye Park, Alix Ashare, Peter F. Wright, Jiwon Lee
This study analyzes serum IgG repertoires in vaccinated cystic fibrosis patients, identifying convergent antibodies that target the SARS-CoV-2 receptor-binding domain and show strain-specific neutralization.
bioRxiv · Jul 10, 2026 · PreprintImmunology