Maternal vaccination timing shapes the composition and maturation of antibody clonotypes transferred to the newborn
Aisha Yesbolatova, Lowrey Peyton, Nicholas C. Curtis, Tae Kim, Jinyoung Yoon, Hunter J. Melton, Noor M Taher, Tae-Geun Yu, Brian H. Kim, Dhvanir N. Kansara, Matthew R. Stoner, Ellison Ober, Emma Varella, Pieter Pannus, Larissa DeBrabandere, , Jiwon Lee
This study examines how maternal vaccination timing affects antibody clonotype transfer to newborns, finding that earlier vaccination leads to more diverse but less persistent clonotypes, while later vaccination results in more persistent, affinity-matured antibodies in cord blood.
bioRxiv · Jul 16, 2026 · PreprintImmunology