Circular RNA profiling revealed an evolutionarily conserved circACACA promotes liver lipid metabolism, oxidative stress, and autophagy disorder in a ceRNA manner
Jing Zhao, Shunshun Han, Jialin Xiang, Yuqi Chen, Xiyu Zhao, Wenjuan Wang, Yao Zhang, Qing Chun Zhu, Chang Liu, Huadong Yin
This study identifies circACACA as an evolutionarily conserved circRNA that disrupts lipid metabolism and induces oxidative stress and autophagy disorder in NAFLD through a ceRNA mechanism.
PLoS Genetics · Dec 18, 2025Peer-reviewedCell Biology