ClpS directs degradation of primary N-end rule substrates in Mycolicibacterium smegmatis
Christopher J. Presloid, Jialiu Jiang, Pratistha Kandel, Henry R. Anderson, Patrick C. Beardslee, Thomas M. Swayne, Karl R. Schmitz
This study identifies ClpS as a key regulator of primary N-end rule proteolysis in Mycolicibacterium smegmatis, showing it binds canonical N-degrons and enhances substrate specificity for ClpC1P1P2 protease.
Molecular Microbiology · Dec 3, 2024Peer-reviewedBiochemistry