Karl R. Schmitz

This study shows phosphoarginine modulates ClpC2 oligomerization and repressor activity, linking pArg levels to transcriptional regulation in mycobacteria.

The paper identifies 33 novel phosphoinositide-binding effectors from three intracellular pathogens, revealing conserved α-helical structural motifs distinct from eukaryotic lipid-binding domains.

This study identifies CsdA as the first NAD+ cap reader protein in E. coli, showing it binds NAD+ capped RNA and enhances decapping activity.

This study identifies ClpS as a key regulator of primary N-end rule proteolysis in Mycolicibacterium smegmatis, showing it binds canonical N-degrons and enhances substrate specificity for ClpC1P1P2 protease.

The paper screens C-terminal pentapeptide sequences in E. coli to identify potent proteolytic degrons, finding that ssrA-like tags are highly effective and selectively recognized by ClpXP proteases.

The paper identifies ClpI, a new class of Clp unfoldases in Actinomycetota, distinct from ClpB and ClpC, with unique structural and functional features.