Integrating Hi-C and FISH data for modeling 3D organizations of chromosomes
Ahmed Abbas, Xuan He, Jing Niu, Bin Zhou, Guangxiang Zhu, Tszshan Ma, Jiangpeikun Song, Juntao Tony Gao, Michael Q. Zhang, Jianyang Zeng
This paper introduces GEM-FISH, a method that integrates Hi-C and FISH data to improve 3D chromosome modeling, showing better accuracy in TADs, compartments, and super-enhancer distributions than Hi-C alone.
Nature Communications · May 3, 2019Peer-reviewedBioinformatics