Non-canonical histone H3.3 and its chaperones HIRA and DAXX participate in the regulation of KSHV latency
Sarah McMahon, Vaibhav Jain, Viacheslav M. Morozov, Sunantha Sethuraman, Jianhong Hu, Ritu Shekhar, Netanya Keil, P. Turner, Alexander M. Ishov, Rolf Renne
This study shows that H3.3 and its chaperones HIRA and DAXX regulate KSHV latency by promoting chromatinization and stability of the viral episome.
bioRxiv · Apr 7, 2026 · PreprintMolecular Biology