Single-cell landscape reveals NAMPT mediated macrophage polarization that regulate smooth muscle cell phenotypic switch in pulmonary arterial hypertension
Zuoshi Wen, Liujun Jiang, Fangcong Yu, Xiaodong Xu, Mengjia Chen, Jianing Xue, Pengwei Zhu, Zhangquan Ying, Zhoubin Li, Ting Chen
The paper uses scRNA-seq to analyze pulmonary arteries in PAH and healthy donors, identifying NAMPT-mediated macrophage polarization that drives SMC phenotypic switching.
bioRxiv · Jul 4, 2023 · PreprintMolecular Biology