Phenotypic Bioactivity Prediction as Open-set Biological Assay Querying
Yuze Sun, Xiaoman Zhang, Qiaoyu Zheng, Hanzheng Li, Jianming Zhang, Liang Hong, Yanfeng Wang, Ya Zhang, Weidi Xie
This paper introduces OpenPheno, a multimodal model that predicts bioactivity using phenotypic profiles and natural language descriptions, achieving strong zero-shot performance on unseen assays.
bioRxiv · Mar 3, 2026 · PreprintBioinformatics