Author

Xiaoman Zhang

Harvard UniversityORCID 0000-0002-7696-9366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:contrastive learning· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Yanfeng Wang· 3 shared Weidi XieiD· 2 shared Yuze Sun· 2 shared Hanzheng LiiD· 1 shared Jian Zhang· 1 shared Jianming Zhang· 1 shared Jinghao Feng· 1 shared Jinghao FengiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBioinformatics

Yanfeng Wang

Mutual co-authors in cluster

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3 papers

Recent·Most cited

RELAY: Relational In-Context Learning for Cellular Perturbation Prediction

Yuze Sun, Jinghao Feng, Yanfeng Wang, Weidi Xie, Ya Zhang, Xiaoman Zhang

RELAY predicts cellular responses to perturbations by learning relational patterns from measured data, outperforming existing methods on unseen variable values and combinations.

bioRxiv · Nov 3, 2026 · PreprintCell Biology

Phenotypic Bioactivity Prediction as Open-set Biological Assay Querying

Yuze Sun, Xiaoman Zhang, Qiaoyu Zheng, Hanzheng Li, Jianming Zhang, Liang Hong, Yanfeng Wang, Ya Zhang, Weidi Xie

This paper introduces OpenPheno, a multimodal model that predicts bioactivity using phenotypic profiles and natural language descriptions, achieving strong zero-shot performance on unseen assays.

bioRxiv · Mar 3, 2026 · PreprintBioinformatics

MAP: A Knowledge-driven Framework for Predicting Single-cell Responses for Unprofiled Drugs

Jinghao Feng, Ziheng Zhao, Xiaoman Zhang, Mingfei Liu, Jingyi Chen, Xingran Quan, Jian Zhang, Yanfeng Wang, Ya Ping Zhang, Weidi Xie

MAP predicts single-cell responses to unprofiled drugs using a knowledge-driven framework that integrates biological knowledge and improves performance over baselines.

bioRxiv · Feb 27, 2026 · PreprintBioinformatics