Epithelial-Intrinsic Alterations and Maladaptation to Luminal Metabolites Underlie Persistent Crohn's Disease Pathogenesis
Jianqiao Liu, Ran Zhou, Jason Koval, Peter S. Carbonetto, Candace M. Cham, Ashley M. Sidebottom, Matthew Stephens, Sebastian Pott, Eugene B. Chang, Anindita Basu
The paper investigates whether persistent inflammation in Crohn's disease is due to environmental triggers or intrinsic epithelial changes by comparing organoid and tissue data from patients in remission.
bioRxiv · Aug 4, 2026 · PreprintImmunology