Author

Jiaoyang Xu

The University of Texas Health Science Center at Houston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

Eric BoerwinkleiD· 3 shared Iman Egab· 3 shared James R. LupskiiD· 3 shared Jennifer Ellen PoseyiD· 3 shared Richard A. GibbsiD· 3 shared S. Stephen YiiD· 3 shared Zeynep Coban‐AkdemiriD· 3 shared Alanna MorrisoniD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Eric BoerwinkleORCID

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Author profile →

4 papers

Recent·Most cited

Unveiling the Hidden Rules: Enhancing NMD Prediction for Protein-Truncating Variants

Iman Egab, Jacob Schmidt, Michael A. Cortázar, Jiaoyang Xu, Peter Orchard, Moez Dawood, Tugce Bozkurt‐Yozgatli, Jasmine Koh, Luisa Mestroni, M Taylor, S. Stephen Yi, Daniel G. Calame, Jennifer Ellen Posey, Richard A. Gibbs, Eric Boerwinkle, , Zeynep Coban‐Akdemir

The paper develops a model to predict NMD outcomes for protein-truncating variants using RNA-seq data, achieving ~78% ROC-AUC and identifying non-canonical determinants.

bioRxiv · Oct 9, 2026 · PreprintGenomics

Phase Separation Contributes to Pathogenicity for Nonsense Mediated Decay-Escaping Variant Alleles

Jiaoyang Xu, Jacob Schmidt, Amy Campbell, Tugce Bozkurt‐Yozgatli, Iman Egab, Luisa Mestroni, Matthew Taylor, Jennifer Ellen Posey, Richard A. Gibbs, Eric Boerwinkle, Paul De Vries, Alanna Morrison, S. Stephen Yi, Chad A. Shaw, Claudia M. B. Carvalho, , Zeynep Coban‐Akdemir

This study identifies NMD-escape variants as a distinct class of disease-causing mutations, showing that altered C-terminal regions drive pathogenicity through phase separation.

medRxiv · Dec 2, 2025 · PreprintGenetic & Genomic Medicine

Genomic rare variant mechanisms for congenital cardiac laterality defect: A digenic model approach

Archana Rai, Jonathan Klonowski, Bo Yuan, Karen J. Coveler, Zain Dardas, Iman Egab, Jiaoyang Xu, Philip J. Lupo, A. J. Agopian, Dennis Kostka, Cecilia W. Y. Lo, S. Stephen Yi, Bruce D. Gelb, Christine E. Seidman, Eric Boerwinkle, , Zeynep Coban‐Akdemir

The paper identifies trans-heterozygous digenic variants in laterality defect genes using exome/genome sequencing data from CHD cohorts, finding significant enrichment in laterality cases compared to controls.

The American Journal of Human Genetics · Jun 20, 2025Peer-reviewedGenetic & Genomic Medicine

A novel enterococcus phage endolysin Lys22 with a wide host range against mixed biofilm of Enterococcus faecalis, Staphylococcus aureus and Acinetobacter baumannii

Ziqin Yang, Xue Yan Du, Nannan Hu, Meng-ai Feng, Jiaoyang Xu, Hailin Jiang, Na Zhang, Honglan Huang, Jinghua Li, Hongyan Shi

This paper identifies Lys22, an endolysin from an enterococcus phage, which effectively targets multiple antibiotic-resistant bacteria and inhibits their biofilms and mixed infections.

bioRxiv · Mar 11, 2025 · PreprintMicrobiology