Author

Michael A. Cortázar

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Sujatha JagannathaniD· 4 shared Zeynep Coban‐AkdemiriD· 3 shared Amy E. CampbelliD· 2 shared Iman Egab· 2 shared Jacob Schmidt· 2 shared Rui FuiD· 2 shared Alanna MorrisoniD· 1 shared Alex P. ReineriD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenomics

Sujatha JagannathanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unveiling the Hidden Rules: Enhancing NMD Prediction for Protein-Truncating Variants

Iman Egab, Jacob Schmidt, Michael A. Cortázar, Jiaoyang Xu, Peter Orchard, Moez Dawood, Tugce Bozkurt‐Yozgatli, Jasmine Koh, Luisa Mestroni, M Taylor, S. Stephen Yi, Daniel G. Calame, Jennifer Ellen Posey, Richard A. Gibbs, Eric Boerwinkle, , Zeynep Coban‐Akdemir

The paper develops a model to predict NMD outcomes for protein-truncating variants using RNA-seq data, achieving ~78% ROC-AUC and identifying non-canonical determinants.

bioRxiv · Oct 9, 2026 · PreprintGenomics

Genomic stop codon scanning reveals quantitative principles of nonsense-mediated mRNA decay

Michael A. Cortázar, Jacob Schmidt, Iman Egab, Zeynep Coban‐Akdemir, Sujatha Jagannathan

The paper quantitatively analyzes NMD activity for various PTCs in the LMNA gene, revealing new positional and sequence context dependencies beyond existing binary rules.

bioRxiv · Dec 23, 2025 · PreprintGenomics

Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay

Divya Kolakada, Rui Fu, Nikita Biziaev, Alexey V. Shuvalov, Mlana Lore, Amy E. Campbell, Michael A. Cortázar, Marcin Piotr Sajek, Jay R. Hesselberth, Neelanjan Mukherjee, Elena Z. Alkalaeva, Zeynep Coban‐Akdemir, Sujatha Jagannathan

The paper identifies the amino acid preceding a premature termination codon as a key determinant of nonsense-mediated mRNA decay efficiency.

Cell Genomics · May 19, 2025Peer-reviewedMolecular Biology

Truncated RNA-binding protein production by DUX4-induced systemic inhibition of nonsense-mediated RNA decay

Amy E. Campbell, Michael C. Dyle, Roberto Albanese, Tyler Matheny, Kavitha Sudheendran, Michael A. Cortázar, Thomas E. Forman, Rui Fu, Austin E. Gillen, Marvin H. Caruthers, Stephen N. Floor, Lorenzo Calviello, Sujatha Jagannathan

The paper shows that inhibiting NMD in FSHD leads to widespread production of truncated RNA-binding proteins, some of which are toxic and can be detected in patient samples.

Cell Reports · Jun 1, 2023Peer-reviewedGenomics