Structural insights on the ligand selectivity of the mouse trace amine-associated receptor TAAR7e
Yingjian Liu, Junhong He, Jiahui Sun, Chen Zhang, Hanyi Zhuang, Jiaqi Song, Peipei Shi, Weihong Liu
This study investigates the molecular mechanisms of ligand selectivity in mTAAR7e using homology modeling, structure-activity analysis, and mutagenesis, revealing structural determinants for preference toward longer carbon chains and tertiary amines.
iScience · Jul 14, 2026Peer-reviewedMolecular Biology