FAM134B isoform 2/RETREG1-2 defines a calnexin-TOLLIP-coupled ER-phagy pathway that restricts Ebola virus glycoprotein and is antagonized by VP40 through macro-autophagy
Jing Zhang, Tao Wang, Jiaxin Wen, Jing Quan Lan, Sunan Li, Yong‐Hui Zheng
This paper identifies RETR1-2 as an ER-phagy receptor that restricts Ebola virus glycoprotein through a calnexin-TOLLIP pathway, which is counteracted by VP40 via macro-autophagy.
bioRxiv · Apr 2, 2026 · PreprintMicrobiology