Single residue changes to the histone core catalyze neofunctionalization and impose fitness trade-offs
Zachary H. Harvey, Kathryn M Stevens, Jian Yi Kok, Akihisa Osakabe, Jiaying Liu, Tobias Warnecke, Frédéric Berger
This study shows that single residue changes in histone H2A.Z can lead to new functions and fitness trade-offs by altering gene expression.
Cell Reports · Jul 29, 2025Peer-reviewedMolecular Biology