Tobias Warnecke

The paper maps single-residue effects of H2A and H2A.Z nucleosome-core variations on cellular functions, revealing non-chromatin regulatory roles and stress-related benefits.

This study deletes nine NAPs from E. coli to create a strain lacking native chromatin, revealing gene expression homogenization and demonstrating that bacterial life can proceed without chromatin proteins.

The paper investigates the presence of bacteriocins in archaea and archaeocins in bacteria, finding that over 20% of known bacteriocins have archaeal homologs and some archaeocins are common in bacterial genomes.

This study identifies and characterizes cinquedea, a bactericidal phospholipase from the archaeon Haloferax larsenii that kills halophilic bacteria by damaging their cell membranes.

This study investigates reverse gyrase activity in Thermococcus kodakarensis, showing it stabilizes regulatory regions by acting on hyper-negatively supercoiled DNA.

This study identifies antagonistic interactions between archaea and bacteria by analyzing genome sequences and demonstrating the antibacterial activity of archaeal peptidoglycan hydrolases.

This study shows that single residue changes in histone H2A.Z can lead to new functions and fitness trade-offs by altering gene expression.

This study shows that histones are essential and form chromatin in bacteria, with a unique DNA binding mode compared to archaea and eukaryotes.

The paper uses deep mutational scanning to analyze the fitness landscape of an RNA structure, showing how mutational effects depend on multiple conformational states.

The paper shows that cytosine methylation affects mutation rates at neighboring nucleotides differently in humans, Arabidopsis, and rice, with species-specific patterns.

This study expresses archaeal histones in E. coli to investigate chromatinization challenges, finding nucleosome occupancy correlates with transcriptional repression but minimal growth impact.

The paper investigates HGT patterns in Geobacillus, finding three chromosomal zones enriched for horizontal gene flow, with restrictions linked to chromosomal organization during sporulation.