Clinically relevant mutations of mycobacterial GatCAB inform regulation of translational fidelity
Yang-Yang Li, Rong-Jun Cai, Jiaying Yang, Tamara L. Hendrickson, Ye Xiang, Babak Javid
The paper investigates clinically relevant mutations in mycobacterial GatCAB, showing they reduce complex stability and increase translational errors, which can be mitigated by trehalose.
mBio · Jul 6, 2021Peer-reviewedMolecular Biology