Babak Javid

This paper identifies a small molecule that enhances translational fidelity in mycobacteria without reducing translation speed, targeting ribosomal protein S5 to combat antibiotic tolerance.

This study shows that antibodies against Mtb enhance immunity via NLRP3 inflammasome activation in mice, independent of Fc receptors, and this mechanism applies to polyclonal sera in rhesus macaques.

The paper investigates clinically relevant mutations in mycobacterial GatCAB, showing they reduce complex stability and increase translational errors, which can be mitigated by trehalose.

The paper shows that GidB-mediated 16S rRNA methylation in mycobacteria enhances discrimination of mischarged tRNAs, improving translational fidelity in high mistranslation environments.

The paper measures stop codon readthrough in Drosophila across development and tissues, finding it varies with age and tissue type, being highest in neurons.