BioLACE: unifying spatial geometry and marker priors for cohesive cell-type clustering in spatial transcriptomics
Haoran Qin, Yunfei Hu, Yuling Zhu, Jihoon Baek, Weiman Yuan, Shan Meltzer, Xin Maizie Zhou
BioLACE improves spatial clustering in transcriptomics by integrating spatial geometry and marker gene priors within a VAE framework, achieving better cell type accuracy and interpretability.
bioRxiv · Dec 2, 2025 · PreprintGenomics