Shan Meltzer

Benchmarking cell type annotation in spatial transcriptomics: resolving cellular hierarchies, biological fidelity, and dynamic cell states

This study benchmarks 20 cell type annotation methods on spatial transcriptomics data to evaluate their performance in resolving cell types, subtypes, and biological organization across diverse datasets.

Spatial transcriptomics reveals organizational properties of the mouse spinal cord and alterations in neuropathic pain

This study uses spatial transcriptomics to map the organization of the mouse spinal cord and identifies changes in neuronal subtypes and communication patterns in neuropathic pain.

Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin

This study introduces an in vivo two-photon imaging method to visualize LTMR axon morphology in mouse skin during development and in adults, enabling longitudinal analysis of sensory circuit structure and function.

BioLACE: unifying spatial geometry and marker priors for cohesive cell-type clustering in spatial transcriptomics

BioLACE improves spatial clustering in transcriptomics by integrating spatial geometry and marker gene priors within a VAE framework, achieving better cell type accuracy and interpretability.

C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway

This study identifies a C-LTMR-spinoparabrachial pathway that mediates wet dog shakes in mice by detecting oil droplets and triggering rapid removal of foreign particles from hairy skin.

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

This study shows that γ-protocadherin isoforms are critical for synapse formation and peripheral branching in touch sensory neurons, and their loss disrupts corticospinal synapses.

A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs