Aquaporin-3 amplifies arsenite genotoxicity as a dose-dependent gene-by-environment interaction in human cells
Shiwei Yin, Feng Bi, Maryam Vaziripour, Shannon E. Slewitzke, Gail F. Fernandes, Jihye Yun, Christopher Ian Amos, Jun Xia
This study shows that AQP3 amplifies arsenite-induced DNA damage in a dose-dependent manner, indicating a gene-by-environment interaction that influences genotoxicity.
bioRxiv · Sep 24, 2026 · PreprintCell Biology