Jun Xia

Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability

The paper identifies lung cancer susceptibility copy number variants (CNVs) and shows their potential role in genomic instability through association analyses and functional validation.

Aquaporin-9 and aquaporin-10 but not aquaporin-3 confer susceptibility to dimethylarsinic acid genotoxicity in human cells

The paper shows that AQP9 and AQP10 increase DMA(V)-induced DNA damage in human cells, while AQP3 and AQP7 do not, indicating their role in arsenic genotoxicity.

Aquaporin-3 amplifies arsenite genotoxicity as a dose-dependent gene-by-environment interaction in human cells

This study shows that AQP3 amplifies arsenite-induced DNA damage in a dose-dependent manner, indicating a gene-by-environment interaction that influences genotoxicity.

Somatic copy-number alteration signatures reveal sex-divergent aging trajectories accelerated in cancer

This paper develops ultra-CNA, a high-resolution single-cell analysis pipeline for copy-number alterations, revealing sex-divergent aging trajectories and accelerated aging in cancer.

Dynamic uterine microenvironment drives endometrial adenocarcinoma carcinogenesis and progression

This study uses scRNA-seq on uterine blood samples to analyze immune and stromal changes in endometrial cancer progression, identifying neutrophil signatures that stratify disease states.

Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression

The paper presents an isoform-level lung cell atlas using single-cell long-read RNA-sequencing, revealing genetic effects on isoform regulation that improve cell-type classification and identify novel variants associated with lung cancer risk.

Single-cell Genomic Copy Number Evolution Reveals Frequent Loss of the Y chromosome in Esophageal Adenocarcinoma

This study uses single-nucleus DNA and RNA sequencing to analyze LOY in EAC and find its association with tumor heterogeneity and immune evasion.

Context-aware single-cell multiome approach identified cell-type specific lung cancer susceptibility genes

The paper identifies cell-type specific lung cancer susceptibility genes by integrating single-cell multi-omics data with GWAS loci.