Remodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO
Ruiyuan Zheng, Kyle Moynahan, Theodoros Georgomanolis, Egor A. Pavlenko, Simon Geißen, Athanasia Mizi, Simon Grimm, Harshal Nemade, Rizwan Rehimi, Jil Bastigkeit, Jan‐Wilm Lackmann, Matti Adam, Álvaro Rada-Iglesias, Peter Nüernberg, Anna Klinke, , Yulia Kargapolova
This study shows MPO enters endothelial cell nuclei, binds chromatin non-enzymatically, and regulates EndMT and EC fate through chromatin remodeling and interaction with ILF3.
iScience · Jan 12, 2024Peer-reviewedGenomics