Jan‐Wilm Lackmann

This study shows that male obesity affects adipose mitochondrial function in offspring via the let-7-DICER axis, with reversible effects observed in both mice and human semen.

The paper shows that mechano-osmotic changes in pluripotent stem cells influence chromatin state and fate transitions by integrating mechanical and biochemical signals.

This study identifies a unique glycogen metabolism in naked mole-rat hearts during ischaemia, involving liver-like mechanisms and amylase activation for enhanced glycolytic flux and ATP maintenance.

The paper investigates the role of SMG8 and SMG9 in maintaining NMD robustness by analyzing transcriptome-wide changes and UPF1 interactome in human cells with genetic modifications.

This study shows MPO enters endothelial cell nuclei, binds chromatin non-enzymatically, and regulates EndMT and EC fate through chromatin remodeling and interaction with ILF3.

The paper investigates the role of RNPS1 in splicing regulation and NMD by analyzing transcriptome-wide effects of its knockdowns, finding that RNPS1 primarily regulates splicing through distinct domains and interacts with splicing factors.

This study shows that UPF3A and UPF3B redundantly activate nonsense-mediated mRNA decay in human cells, with their combined depletion inhibiting NMD and upregulating substrates.

The paper shows that RBPMS controls mRNA translation in pluripotent hESCs to preset cardiac fate competence, which is critical for cardiogenesis.

This study identifies PCK2 as a biomarker for renal function 12 months after living donor kidney transplantation using proteomic analysis of urinary extracellular vesicles.