New insights underlying the early events of dopaminergic dysfunction in Parkinson's Disease
Hannah L. Dela Cruz, Esther L. Dela Cruz, Cody Zurhellen, Herbert T. York, Jim A. Baun, Joshua L. Dela Cruz, Jay S. Dela Cruz
This paper shows that elevated alpha-MSH in Parkinson's disease models impairs autophagy, leading to alpha-synuclein accumulation and motor deficits, which can be temporarily reversed by dopamine replacement.
bioRxiv · Sep 27, 2020 · PreprintNeuroscience