A novel retinoic acid analog, 4-Amino-2-Trifluoromethyl-Phenyl Retinate (ATPR) triggers differentiation and is effective in the treatment of Acute Promyelocytic Leukemia
Jing Bao, Yan Zhi Du, Lanlan Li, Liang Ping Xia, Feihu Chen
This study investigates ATPR's therapeutic effect on APL by showing it induces differentiation and modulates PI3K/AKT, ERK, and Notch signaling in a xenograft model.
bioRxiv · Jul 9, 2020 · PreprintMolecular Biology