Self-adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Zhen‐Ping Zou, Xin‐Ge Wang, Xuanren Shi, Shu‐Ting Sun, Jing Mi, Xiao Peng Zhang, Bin‐Cheng Yin, Ying Qian Zhou, Bang‐Ce Ye
This paper develops an engineered probiotic that targets tumors through lactate-sensing and quorum-sensing circuits, improving safety and therapeutic effectiveness in colorectal tumor models.
Advanced Science · May 28, 2025Peer-reviewedSynthetic Biology