An ancient gene duplication is implicated in virulence in the human pathogen, Histoplasma
Victoria E. Sepúlveda, Jingbaoyi Li, David A. Turissini, Jonathan A. Rader, Oliver Kompathoum, Daniel Ricardo Matute
The paper identifies two new -amylase genes in Histoplasma and shows their roles in -glucan biosynthesis and virulence, revealing ancient gene duplications.
bioRxiv · Feb 25, 2026 · PreprintMicrobiology