HnRNPAB-targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimers disease-associated alternative splicing
Tao Jiang, Xingjun Xu, Yaqiong Yu, Caixin Zhu, Chao Ma, Yu Tang, Lingxia Min, Mingliang Tan, Jialin Bai, Zhou Feng, Jingming Hou
This study identifies AB332, a hnRNPAB isoform, as a repressor of MAPT exon 10 inclusion and shows that targeting hnRNPAB with antisense oligonucleotides reduces tau pathology and cognitive deficits in AD mice.
bioRxiv · Jul 3, 2026 · PreprintMolecular Biology