Tao Jiang

This study identifies AB332, a hnRNPAB isoform, as a repressor of MAPT exon 10 inclusion and shows that targeting hnRNPAB with antisense oligonucleotides reduces tau pathology and cognitive deficits in AD mice.

This paper develops a low-intensity focused ultrasound (LIFU) strategy to enhance meningeal lymphatic drainage, preventing cognitive decline in Alzheimer's disease models.

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

The paper identifies 31 projectome-defined subtypes of hypothalamic neurons and six modular subnetworks, revealing the organization of axon projections and their functional roles.

The paper characterizes the organization of midbrain cholinergic neurons by reconstructing their axonal projections and identifying distinct subtypes based on their connectivity patterns.

The paper systematically characterizes short intronic splicing-regulatory elements by analyzing their effects on exon splicing using a minigene approach.

The paper creates a whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nucleus, revealing distinct projection patterns and input sources.

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.