Spatial mapping of α-synuclein seeding activity and pathology using immunofluorescence-integrated quiescent seed amplification
Hengxu Mao, Yaoyun Kuang, Zerui Wang, Hao Lin, Wei Dai, Tingting Gan, Zhengxiao He, Wen-quan Zou, Chao Ma, Yue Huang, Jinkun Huang, Pingyi Xu
This paper introduces IF-QSAA, a method that maps alpha-synuclein seeding activity and pathology in tissue, revealing white-matter enrichment and resolving hemispheric asymmetry in Parkinson's disease.
bioRxiv · Mar 26, 2025 · PreprintNeuroscience