NeurosciencebioRxivPreprint
Spatial mapping of α-synuclein seeding activity and pathology using immunofluorescence-integrated quiescent seed amplification
Hengxu Mao, Yaoyun Kuang, Zerui Wang…·Pingyi Xu
This paper introduces IF-QSAA, a method that maps alpha-synuclein seeding activity and pathology in tissue, revealing white-matter enrichment and resolving hemispheric asymmetry in Parkinson's disease.