Butyrate blocks specific histone acetylation by preventing recruitment of p300 to acetylated histones
Muwei Jiang, Anthi Psoma, Jinxiao Lyu, Maria Gabriella Chiariello, Rutger Modderman, Frans Bianchi, Danny Incarnato, Siewert J. Marrink, Iris H. Jonkers, Geert van den Bogaart
This study shows that butyrate increases global histone acetylation by preventing p300 recruitment to acetylated histones, rather than targeting specific genomic regions.
bioRxiv · Oct 10, 2025 · PreprintMolecular Biology