Author

Rutger Modderman

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Iris H. JonkersiD· 3 shared Aarón D. Ramírez-SáncheziD· 2 shared Cisca WijmengaiD· 2 shared Eline SmitsiD· 2 shared Joram MooiweeriD· 2 shared Renée MoerkensiD· 2 shared Sebo WithoffiD· 2 shared Anthi PsomaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

Iris H. JonkersORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Autologous biopsy-derived co-culture platform for interrogation of intestinal epithelial-T cell crosstalk

Joram Mooiweer, Sajid Anwar, Nathan Vinícius Ribeiro, Aarón D. Ramírez-Sánchez, Hanna L. Simpson, Eline Smits, Renée Moerkens, Jody Gelderloos-Arends, Rutger Modderman, Gieneke Gonera-de Jong, Margreet M. S. Wessels, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers

This paper develops an autologous co-culture system to study human intestinal IEL-epithelial interactions, showing both non-destructive and cytotoxic responses under different conditions.

bioRxiv · Aug 7, 2026 · PreprintImmunology

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

Renée Moerkens, Joram Mooiweer, Eline Smits, Marijn Berg, Aarón D. Ramírez-Sánchez, Rutger Modderman, Jens Puschhof, Cayetano Pleguezuelos‐Manzano, Robert J. Barrett, Cisca Wijmenga, Iris H. Jonkers, Sebo Withoff

This study compares hiPSC-derived intestinal epithelial cells cultured in organoids, Transwells, and intestine-on-chip systems, showing that the latter promotes stronger gene expression related to nutrient and drug metabolism and a more mature state.

Stem Cell Reports · Nov 13, 2025Peer-reviewedCell Biology

Butyrate blocks specific histone acetylation by preventing recruitment of p300 to acetylated histones

Muwei Jiang, Anthi Psoma, Jinxiao Lyu, Maria Gabriella Chiariello, Rutger Modderman, Frans Bianchi, Danny Incarnato, ‪Siewert J. Marrink, Iris H. Jonkers, Geert van den Bogaart

This study shows that butyrate increases global histone acetylation by preventing p300 recruitment to acetylated histones, rather than targeting specific genomic regions.

bioRxiv · Oct 10, 2025 · PreprintMolecular Biology