Geert van den Bogaart

The paper shows that alpha-synuclein phase separation can form Lewy body-like structures without pre-existing seeds, suggesting a new mechanism for neurodegeneration.

The paper uses STED microscopy to study CENP-A organization during mitosis in human cells, finding stage-dependent spatial variations in its structure.

This study shows that Catestatin improves heart metabolic flexibility by enhancing mitochondrial structure and function through binding to ATP synthase.

The paper shows that DCs use reverse MHC class I signaling to polarize their MTOC and Golgi toward T cells, enabling localized IL-12 release for T cell activation.

The paper shows that 4-HNE increases SYT1 expression in macrophages, which inhibits phagocytosis of bacteria.

This study shows that 4-HNE suppresses IL-10 production in sepsis while leaving IL-6 and TNF- unaffected, through mechanisms involving HIF-1 and NF-κB signaling.

This study shows that inhibiting SHP-1/2 reduces antigen cross-presentation by macrophages and dendritic cells, potentially limiting the effectiveness of PD-1 checkpoint therapy.

This study shows that butyrate increases global histone acetylation by preventing p300 recruitment to acetylated histones, rather than targeting specific genomic regions.

This study identifies a congenital disorder of glycosylation caused by a missense variant in the second starting methionine of syntaxin-5, leading to loss of the short isoform and multisystem disease.