Interaction between histone residue H3K56 and mismatch repair protein MutSβ drives CAG repeat expansion
Jinzhen Guo, Wei Yang, Guo‐Min Li
The paper shows that H3K56 interacts with MutSβ to recruit it to chromatin, promoting CAG repeat expansion, and suggests targeting this interaction to prevent neurodegenerative disorders.
bioRxiv · Sep 29, 2024 · PreprintMolecular Biology