Wei Yang

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning

The paper describes a method to generate human embryo-like structures by pre-patterning stem cells and mixing them, resulting in models with extended anterior-posterior organization and neural features.

Carcinogen-induced DNA adducts amplify APOBEC mutagenesis through nucleotide excision repair

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.

Interaction between histone residue H3K56 and mismatch repair protein MutSβ drives CAG repeat expansion

The paper shows that H3K56 interacts with MutSβ to recruit it to chromatin, promoting CAG repeat expansion, and suggests targeting this interaction to prevent neurodegenerative disorders.