Calpain cleaves the carboxyl terminus of TRPV1 and modulates receptor tachyphylaxis
Jinyan Jiang, Xiaochen Wang, Jing Yang, Shuwen Gao, Jixuan Xu, Jiao Liu, Yun Wang, Ping Liang, Ying Zhang
This study shows that calpain cleaves TRPV1's carboxyl terminus, reducing its membrane localization and increasing resistance to tachyphylaxis during repeated capsaicin exposure.
bioRxiv · Apr 28, 2025 · PreprintNeuroscience