Preclinical trial supports dual inhibition of BCL2 and Aurora kinase A for MYCN-amplified high-risk neuroblastoma
Alvin Kamili, Brandon A. Hearn, Isabella Temelkoska, Joan Solomon, Madeleine S. Wheatley, Christina H.T. Bui, Caroline J. Atkinson, Leith-Justin Elhassadi, Sadia Qureshi, Jayne E. Murray, Roxanne Cadiz, Andrew J. Gifford, Lujing Cui, Lewis Crowley, Angela Lin, , Jamie I. Fletcher
This study identifies venetoclax-alisertib as a promising combination therapy for high-risk neuroblastoma, particularly effective in MYCN-amplified models, with improved survival and reduced toxicity.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology