BiophysicsbioRxivPreprint
Human Metalloenzymes Are Disproportionately Linked to Disease: The HEAM Structural Annotation Resource
Elizabeth Miller, Samuel Lim, Matthew M. Copeland, Joanna Sarah Gershkoff Slusky
The paper introduces HEAM, a dataset of human metalloproteins annotated for metal-binding sites and catalytic function, showing metalloenzymes are enriched in disease-related variants and pathways.
DOI 10.64898/2026.10.09.758104