Samuel Lim

The paper introduces HEAM, a dataset of human metalloproteins annotated for metal-binding sites and catalytic function, showing metalloenzymes are enriched in disease-related variants and pathways.

The paper introduces an algorithm to accurately count strands in bacterial outer membrane beta-barrels, achieving 97% accuracy on 571,760 structures from AlphaFold2.

The paper evaluates two cell-based assays for detecting drug-induced condensation of SARS-CoV-2 nucleocapsid protein, finding they provide complementary information to traditional high-content screens.

This study uses evolutionary models to design highly divergent protein variants with enhanced functional properties while maintaining structure.

This study investigates SAHS proteins from tardigrades, showing they protect biological structures from desiccation by preventing liposome fusion and enhancing microbial survival.

The paper identifies extremotolerant proteins that form condensates and protect human cells from apoptosis, including a synthetic protein and a region of ApoE.