Protection against disseminated disease following reinfection with Mycobacterium tuberculosis requires CD8+ lymphocytes
Andrew W Simonson, Michael C Chao, E Grace Bothwell, Feng Shan, Mark A Rodgers, Luke E Hood, Forrest Hopkins, Michael R Chase, Alanna Callendrello, Alexander A Smith, Ryan J Kelly, Cassaundra L Ameel, Edwin Klein, Jennifer Schober, Kara Kracinovsky, , JoAnne L Flynn
This study shows that CD8+ lymphocytes are essential for preventing Mtb dissemination during reinfection, highlighting their non-redundant role in concomitant immunity.
bioRxiv · Nov 3, 2026 · PreprintImmunology