Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases
Marina Corbella, Joe Bravo, Andrey O. Demkiv, Ana Rita Calixto, Kitty Sompiyachoke, Céline Bergonzi, Alfie-Louise R. Brownless, Mikael H. Elias, Shina Caroline Lynn Kamerlin
This study investigates the catalytic mechanisms and substrate specificity of the lactonase GcL, revealing its promiscuity in reaction mechanisms and broad substrate acceptance.
JACS Au · Aug 23, 2024Peer-reviewedBiochemistry