Alfie-Louise R. Brownless

Disease-Causing Mutations Alter the Interplay Between Loop Dynamics and Catalysis in the Protein Tyrosine Phosphatases SHP-1 and SHP-2

This study investigates how disease-causing mutations in SHP-1 and SHP-2 affect WPD-loop dynamics and catalysis, revealing their role in altering enzyme function and providing insights for targeted therapy.

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases

This study investigates the catalytic mechanisms and substrate specificity of the lactonase GcL, revealing its promiscuity in reaction mechanisms and broad substrate acceptance.