Impaired maturation of wild-type superoxide dismutase 1 associated with neurodegeneration in Parkinson disease brain and a novel murine model
Amr H. Abdeen, Benjamin Guy Trist, Sara Nikseresht, Richard Harwood, Stéphane Roudeau, Benjamin Darcy Rowlands, Fabian Kreilaus, Veronica Cottam, David Mor, Miriam Richardson, Joel Siciliano, Julia Forkgen, Greta Schaffer, Sian Genoud, Anne A. Li, , Kay L. Double
The paper investigates wild-type SOD1 misfolding in Parkinson's disease using proteomics and a novel mouse model, showing mismetallation and altered post-translational modifications contribute to pathology and dopamine neuron degeneration.
bioRxiv · Oct 29, 2024 · PreprintNeuroscience