NeurosciencebioRxivPreprint
Impaired maturation of wild-type superoxide dismutase 1 associated with neurodegeneration in Parkinson disease brain and a novel murine model
Amr H. Abdeen, Benjamin Guy Trist, Sara Nikseresht…·Kay L. Double
The paper investigates wild-type SOD1 misfolding in Parkinson's disease using proteomics and a novel mouse model, showing mismetallation and altered post-translational modifications contribute to pathology and dopamine neuron degeneration.
DOI 10.1101/2024.10.29.620972